[迷走神经切断术对大鼠外周血胰岛素分泌及前列腺素E2浓度的影响]

[Effect of truncal vagotomy on insulin secretion and prostaglandin E2 concentration in the peripheral blood of rats].

作者信息

Kuzin M I, Morenkova S A, Karelin A A

出版信息

Biull Eksp Biol Med. 1980 Apr;89(4):400-1.

Abstract

Immunoreactive insulin, glucose and prostaglandin E2 blood content was studied in rats after truncal vagotomy. It was shown that the content of blood plasma glucose did not change after the operation. On the 2nd postoperative day, the content of insulin was similar to that in sham-operated animals. It slightly decreased by the 14th postoperative day and physiologically remained within normal. The level of PGE2 rose abruptly on the second day and fell insignificantly on the 14th day, but did not reach the level recorded in sham-operated rats. Since secreted insulin provides normoglycemia in rats, it can be inferred that function of the insular apparatus is not disturbed after vagotomy over the experimental period. It is suggested that elevated output of PGE2 induced by vagotomy may be in favour of exogenous application of prostaglandins to depress gastric secretion.

摘要

对接受迷走神经干切断术的大鼠的免疫反应性胰岛素、葡萄糖和前列腺素E2的血液含量进行了研究。结果表明，手术后血浆葡萄糖含量没有变化。术后第2天，胰岛素含量与假手术动物相似。到术后第14天略有下降，但仍保持在生理正常范围内。PGE2水平在第2天突然升高，在第14天略有下降，但未达到假手术大鼠记录的水平。由于分泌的胰岛素可使大鼠血糖正常，因此可以推断在实验期间迷走神经切断术后胰岛装置的功能未受干扰。有人提出，迷走神经切断术引起的PGE2分泌增加可能有利于外源性应用前列腺素抑制胃酸分泌。