Hell N S, de Aguiar Pupo A
J Auton Nerv Syst. 1979 Oct;1(1):93-101. doi: 10.1016/0165-1838(79)90008-0.
The role of the autonomic nervous system in control of the acute and the late-phase of insulin secretion was studied in mongrel dogs before and after bilateral severance of the vagus, splanchnic, and vagus plus splanchnic nerves. Glucose-stimulated acute insulin secretion increased after splanchnicotomy or transection of both autonomic nerves but remained unchanged after vagotomy alone. Late-phase insulin secretion was not altered by transection of any of the nerves alone or in combination; similar results were obtained as to fasting insulin levels. In contrast, fasting glycemia was increased after vagotomy and decreased after splanchnicotomy. These findings disclose tonic sympathetic and parasympathetic influences on blood glucose basal concentration and indicate an acute inhibitory role of the sympathetic system on insulin secretion.
在杂种犬双侧切断迷走神经、内脏神经以及迷走神经加内脏神经之前和之后，研究了自主神经系统在控制胰岛素分泌的急性期和晚期阶段中的作用。在切断内脏神经或切断双侧自主神经后，葡萄糖刺激的急性胰岛素分泌增加，但仅切断迷走神经后则保持不变。单独或联合切断任何神经均未改变晚期胰岛素分泌；空腹胰岛素水平也得到了类似结果。相反，切断迷走神经后空腹血糖升高，切断内脏神经后空腹血糖降低。这些发现揭示了交感神经和副交感神经对血糖基础浓度的紧张性影响，并表明交感神经系统对胰岛素分泌具有急性抑制作用。
