[Change in the cross reactivity of MIF producers during the course of the immune response in the H-2 system].

Lymphocytes B10D2 anti-B10 (anti-KbIbDb) produce MIF when incubated with spleen cells of the recombinant KbIb-bearing R107 and Db-bearing R101 lines, possessing either public or private H-2 specificities of the immunizing complex. Cross reactivity revealed in the reaction with "unrelated" lines one week after immunization by allogeneic tumour disappeared during the second week; simultaneously the intensity of the reaction to KbIb and Db region products changes. The cross reaction of anti-Kb MIF producers obtained one week after immunization with cells of Kba and Kbd mutants disappeared two weeks after immunization: the migration inhibition which occurred one week after immunization turns to stimulation during the second week, while the degree of inhibition in the reaction with B10 cells remains unchanged.