Dinovo E C, Bost R O, Sunshine I, Gottschalk L A
Clin Chem. 1978 Oct;24(10):1828-30.
Thioridazine and metabolites were measured in brain, liver, and kidney specimens, obtained postmortem from two subjects whose deaths were related to acute intoxication with thioridazine, by gas-liquid chromatography. Although the absolute concentration measured for thioridazine and metabolites differed in the two cases, the metabolic pattern for each tissue, expressed in terms of the percentage of total drug in each tissue, was quite similar. The brain, liver, and kidney metabolic patterns, however, are in sharp contrast to the plasma metabolite patterns observed for subjects on a therapeutic regimen of thioridazine. As this example demonstrates, postmortem specimens are a valuable (but seldom used) source of human pharmacological data.
通过气液色谱法对两名因硫利达嗪急性中毒死亡的受试者死后获取的脑、肝和肾标本中的硫利达嗪及其代谢产物进行了测定。尽管两例中测得的硫利达嗪及其代谢产物的绝对浓度有所不同，但以各组织中总药物百分比表示的每个组织的代谢模式却非常相似。然而，脑、肝和肾的代谢模式与接受硫利达嗪治疗方案的受试者所观察到的血浆代谢产物模式形成鲜明对比。正如这个例子所示，死后标本是人体药理学数据的宝贵（但很少使用）来源。
