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高效液相色谱法测定生物组织和体液中硫利达嗪及其主要代谢产物

High-pressure liquid chromatographic determination of thioridazine and its major metabolites in biological tissues and fluids.

作者信息

Allender W J

出版信息

J Chromatogr Sci. 1985 Dec;23(12):541-5. doi: 10.1093/chromsci/23.12.541.

DOI:10.1093/chromsci/23.12.541
PMID:4077948
Abstract

A method is described for the determination of thioridazine and its major metabolites in postmortem tissues and fluids by enzymic digestion, followed by a micro-extraction technique using ethyl acetate. Quantitation was performed by using a cyano-bonded silica (mu Bondapak-CN) column packing and a mobile phase consisting of n-octylamine, methanol, and water.

摘要

本文描述了一种通过酶消化法测定死后组织和体液中硫利达嗪及其主要代谢产物的方法,随后采用乙酸乙酯微萃取技术。采用氰基键合硅胶(μ Bondapak-CN)柱填料和由正辛胺、甲醇和水组成的流动相进行定量分析。

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