西咪替丁不会加速小鼠皮肤移植排斥反应。
Cimetidine does not accelerate skin graft rejection in mice.
作者信息
Festen H P, Berden J H, Koene R A
出版信息
Clin Exp Immunol. 1980 Apr;40(1):193-6.
Abstract
The influence of cimetidine on skin graft rejection was studied in a well defined transplantation model of inbred mice. Four allogeneic transplantation combinations with increasing antigenic disparity and one xenograft combination were studied. Cimetidine (25 mg/kg body weight) was administered intraperitoneally at 8-hr intervals until rejection occurred. No differences in graft survival were observed between cimetidine-treated groups and saline-treated controls in any of the combinations studied.
摘要
在一个明确界定的近交系小鼠移植模型中，研究了西咪替丁对皮肤移植排斥反应的影响。研究了四种抗原差异递增的同种异体移植组合和一种异种移植组合。以8小时的间隔腹腔注射西咪替丁（25毫克/千克体重），直至移植排斥发生。在所研究的任何组合中，西咪替丁治疗组和生理盐水治疗对照组之间均未观察到移植存活的差异。
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Cimetidine does not accelerate skin graft rejection in mice.西咪替丁不会加速小鼠皮肤移植排斥反应。
Clin Exp Immunol. 1980 Apr;40(1):193-6.
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引用本文的文献
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Peripheral blood T lymphocytes in patients with duodenal ulcers treated with cimetidine.用西咪替丁治疗的十二指肠溃疡患者的外周血T淋巴细胞
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The effect of cimetidine on antibody synthesis in vitro and in vivo.西咪替丁对体内外抗体合成的影响。
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本文引用的文献
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Unresponsiveness of nude mice to skin allografts.裸鼠对皮肤同种异体移植无反应性。
Transplantation. 1971 Apr;11(4):417-8. doi: 10.1097/00007890-197104000-00012.
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Skin grafts in nude mice. 1. Allografts in nude mice of three genetic backgrounds (BALB-c, C3H, C57-BL).裸鼠的皮肤移植。1. 三种遗传背景（BALB-c、C3H、C57-BL）的裸鼠同种异体移植。
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Primarily vascularized allografts of hearts in mice. The role of H-2D, H-2K, and non-H-2 antigens in rejection.小鼠心脏主要血管化同种异体移植。H-2D、H-2K和非H-2抗原在排斥反应中的作用。
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The non-H-2 histocompatibility loci and their antigens.非H-2组织相容性基因座及其抗原。
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Differential immunogenic expression of an H-2-linked histocompatibility antigen on different tissues. Differences in survival between heart, thyroid, and skin allografts.
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Increased rejection after cimetidine treatment in kidney transplants.西咪替丁治疗肾移植后排斥反应增加。
Transplantation. 1979 May;27(5):358-9. doi: 10.1097/00007890-197905000-00017.
8
Cimetidine: prophylaxis against upper gastrointestinal haemorrhage after renal transplantation.西咪替丁：预防肾移植术后上消化道出血
Br Med J. 1978 Feb 18;1(6110):398-400. doi: 10.1136/bmj.1.6110.398.
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Role of antiserum and complement in the acute antibody-mediated rejection of mouse skin allografts in strain combinations with increasing histoincompatibility.抗血清和补体在组织相容性差异逐渐增大的小鼠品系组合皮肤同种异体移植急性抗体介导排斥反应中的作用
Transplantation. 1977 Sep;24(3):175-82. doi: 10.1097/00007890-197709000-00002.
10
Antibody response and skin graft rejection in the nude mouse.裸鼠的抗体反应与皮肤移植排斥反应
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