Jones R H, Rudge C J, Bewick M, Parsons V, Weston M J
Br Med J. 1978 Feb 18;1(6110):398-400. doi: 10.1136/bmj.1.6110.398.
The incidence of upper gastrointestinal haemorrhage within four months of renal transplantation was studied in two groups of patients. Thirty patients who received prophylactic cimetidine suffered no episodes of upper gastrointestinal haemorrhage, while six of the 33 patients who did not receive cimetidine suffered haemorrhages and one of them died as a result. The difference between the groups was significant. The results suggest that the prophylactic use of cimetidine in patients receiving renal transplants is worth while.
对两组患者进行了肾移植后四个月内上消化道出血发生率的研究。30名接受西咪替丁预防性治疗的患者未发生上消化道出血,而33名未接受西咪替丁治疗的患者中有6人发生出血,其中1人因此死亡。两组之间的差异具有显著性。结果表明,在接受肾移植的患者中预防性使用西咪替丁是值得的。