Cole M A, Crawford D W
Comput Programs Biomed. 1980 Apr;11(2):105-12. doi: 10.1016/0010-468x(80)90118-x.
The program described here provides complete analysis of the indicator dilution curve by incorporating densitometric calibration and logarithmic downslope fit for the widely used Hewlett-Packard 67/97 hand calculator series. Densitometric sensitivity is calculated from the linear regression as the dye calibration factor; thus, direct entry of the dye curve deflections eliminate the necessity to precalculate curve concentration. The program displays appropriate sequential time intervals prompting deflection entry of the upslope and initial exponential downslope of the curve. The remainder of the curve is generated from the logarithmically extrapolated initial downslope, and the area of the curve is then obtained for calculation of cardiac output, mean transit time, and central blood volume. Programming versatility and the rapid (4--5 min) immediate analysis of indicator dilution curves are thus available.
本文所述程序通过为广泛使用的惠普67/97系列手持计算器纳入光密度校准和对数下降斜率拟合，提供了指示剂稀释曲线的完整分析。光密度灵敏度通过线性回归计算得出，作为染料校准因子；因此，直接输入染料曲线偏移消除了预先计算曲线浓度的必要性。该程序显示适当的连续时间间隔，提示输入曲线上升段和初始指数下降段的偏移。曲线的其余部分由对数外推的初始下降段生成，然后获得曲线面积以计算心输出量、平均通过时间和中心血容量。从而实现了编程的多功能性以及对指示剂稀释曲线的快速（4 - 5分钟）即时分析。
