Nakano H, Yamamoto Y, Ohnishi S, Ito K, Imura H
Clin Chim Acta. 1978 Sep 1;88(2):315-9. doi: 10.1016/0009-8981(78)90437-0.
Serum levels of monoamine oxidase were determined in 171 healthy adults and in 77 patients with hepatic diseases by use of a new synthetic derivative of benzylamine, 1-[(4-aminomethylphenyl)azo]-2-naphthol hydrochloride, as substrate. This new compound is more effectively oxidized by serum monoamine oxidase than by benzylamine, currently the most widely used substrate. Diagnosis of hepatic disease was confirmed in all patients by liver histology. The results suggest that the level of this enzyme in serum increases in parallel with the development of hepatic fibrosis.
通过使用苄胺的一种新的合成衍生物——盐酸1-[(4-氨甲基苯基)偶氮]-2-萘酚作为底物，测定了171名健康成年人和77名肝病患者血清中的单胺氧化酶水平。与目前使用最广泛的底物苄胺相比，血清单胺氧化酶对这种新化合物的氧化作用更有效。所有患者均通过肝脏组织学确诊为肝病。结果表明，血清中该酶的水平随着肝纤维化的发展而平行升高。
