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Tolbutamide stimulates Ca2+ influx in islet cells without reducing K+ conductance.

作者信息

Malaisse W J, Carpinelli A R, Herchuelz A

出版信息

Diabetologia. 1980 Jul;19(1):85. doi: 10.1007/BF00258318.

DOI:10.1007/BF00258318
PMID:6993273
Abstract
摘要

相似文献

1
Tolbutamide stimulates Ca2+ influx in islet cells without reducing K+ conductance.甲苯磺丁脲刺激胰岛细胞内的钙离子内流，而不降低钾离子电导。
Diabetologia. 1980 Jul;19(1):85. doi: 10.1007/BF00258318.
2
Opposite effects of tolbutamide and diazoxide on 86Rb+ fluxes and membrane potential in pancreatic B cells.甲苯磺丁脲和二氮嗪对胰腺β细胞中86Rb+通量及膜电位的相反作用。
Biochem Pharmacol. 1982 Apr 1;31(7):1407-15. doi: 10.1016/0006-2952(82)90036-3.
3
Tolbutamide stimulation and inhibition of insulin release: studies of the underlying ionic mechanisms in isolated rat islets.甲苯磺丁脲对胰岛素释放的刺激和抑制作用：对分离的大鼠胰岛潜在离子机制的研究
Diabetologia. 1980;18(2):151-60. doi: 10.1007/BF00290493.
4
Glyburide and tolbutamide induce desensitization of insulin release in rat pancreatic islets by different mechanisms.格列本脲和甲苯磺丁脲通过不同机制诱导大鼠胰岛胰岛素释放脱敏。
Endocrinology. 1992 Oct;131(4):1815-20. doi: 10.1210/endo.131.4.1396327.
5
Mechanisms of tolbutamide-stimulation of pancreatic B cells--a reply.甲苯磺丁脲刺激胰腺β细胞的机制——答复
Diabetologia. 1980 Aug;19(2):162-3. doi: 10.1007/BF00421865.
6
Tolbutamide and diazoxide influence insulin secretion by changing the concentration but not the action of cytoplasmic Ca2+ in beta-cells.甲苯磺丁脲和二氮嗪通过改变β细胞中细胞质Ca2+的浓度而非其作用来影响胰岛素分泌。
Diabetes. 1998 Mar;47(3):365-73. doi: 10.2337/diabetes.47.3.365.
7
Tolbutamide perifusion of rat islets. Sequential changes in calcium, phosphorus, sodium, potassium, and chlorine in single beta cells.大鼠胰岛的甲苯磺丁脲灌流。单个β细胞中钙、磷、钠、钾和氯的顺序变化。
J Clin Invest. 1983 Aug;72(2):478-82. doi: 10.1172/jci110995.
8
Sulphonylureas do not increase insulin secretion by a mechanism other than a rise in cytoplasmic Ca2+ in pancreatic B-cells.磺酰脲类药物并非通过除增加胰腺β细胞胞质钙离子浓度以外的其他机制来增加胰岛素分泌。
Eur J Pharmacol. 1996 Mar 18;298(3):279-86. doi: 10.1016/0014-2999(95)00806-3.
9
Do hypoglycemic sulfonylureas inhibit Na+,K+-ATPase activity in pancreatic islets?降糖磺脲类药物是否会抑制胰岛中的钠钾ATP酶活性？
Am J Physiol. 1985 May;248(5 Pt 1):E491-9. doi: 10.1152/ajpendo.1985.248.5.E491.
10
Free fatty acid accumulation in secretagogue-stimulated pancreatic islets and effects of arachidonate on depolarization-induced insulin secretion.促分泌素刺激的胰岛中游离脂肪酸的积累以及花生四烯酸对去极化诱导的胰岛素分泌的影响。
Biochemistry. 1991 Jul 2;30(26):6372-9. doi: 10.1021/bi00240a004.

引用本文的文献

1
On insulin secretion.关于胰岛素分泌
Diabetologia. 1981 Jul;21(1):1-17. doi: 10.1007/BF03216216.
2
The control of 86Rb efflux from rat isolated pancreatic islets by the sulphonylureas tolbutamide and glibenclamide.磺脲类药物甲苯磺丁脲和格列本脲对大鼠分离胰岛中86Rb外流的控制。
Br J Pharmacol. 1984 Jul;82(3):689-700. doi: 10.1111/j.1476-5381.1984.tb10808.x.
3
Tolbutamide perifusion of rat islets. Sequential changes in calcium, phosphorus, sodium, potassium, and chlorine in single beta cells.大鼠胰岛的甲苯磺丁脲灌流。单个β细胞中钙、磷、钠、钾和氯的顺序变化。

本文引用的文献

1
Tolbutamide stimulation and inhibition of insulin release: studies of the underlying ionic mechanisms in isolated rat islets.甲苯磺丁脲对胰岛素释放的刺激和抑制作用：对分离的大鼠胰岛潜在离子机制的研究
Diabetologia. 1980;18(2):151-60. doi: 10.1007/BF00290493.
2
Opposite effects of hypoglycemic and hyperglycemic sulfonamides upon ionophore-mediated calcium transport.降血糖和升血糖磺酰胺类药物对离子载体介导的钙转运的相反作用。
Biochem Pharmacol. 1980 Jul 1;29(13):1879-82. doi: 10.1016/0006-2952(80)90097-0.
3
Regulation of calcium fluxes in pancreatic islets: glucose-induced calcium-calcium exchange.
J Clin Invest. 1983 Aug;72(2):478-82. doi: 10.1172/jci110995.
4
Identification and metabolism of polyphosphoinositides in isolated islets of Langerhans.胰岛中多磷酸肌醇的鉴定与代谢
Biochem J. 1983 Oct 15;216(1):101-6. doi: 10.1042/bj2160101.
5
Insulinotropic effects of hypoglycaemic and hyperglycaemic sulphonamides: the ionophoretic hypothesis.低血糖和高血糖磺酰胺类药物的促胰岛素分泌作用：离子载体假说
Diabetologia. 1980 Oct;19(4):335-40. doi: 10.1007/BF00280516.
6
Mechanism of the stimulation of insulin release in vitro by HB 699, a benzoic acid derivative similar to the non-sulphonylurea moiety of glibenclamide.HB 699（一种类似于格列本脲非磺酰脲部分的苯甲酸衍生物）在体外刺激胰岛素释放的机制。
Diabetologia. 1985 Sep;28(9):697-703. doi: 10.1007/BF00291979.
胰腺胰岛中钙通量的调节：葡萄糖诱导的钙-钙交换。
Am J Physiol. 1980 Feb;238(2):E96-103. doi: 10.1152/ajpendo.1980.238.2.E96.
4
Stimulus-secretion coupling of glucose-induced insulin release. XXIX. Regulation of 86Rb+ efflux from perfused islets.葡萄糖诱导胰岛素释放的刺激-分泌偶联。二十九。灌注胰岛中86Rb+外流的调节。
Am J Physiol. 1979 Feb;236(2):E139-46. doi: 10.1152/ajpendo.1979.236.2.E139.