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增生性肥胖中的体育锻炼。五、阿托品对血浆胰岛素的影响。

Physical training in hyperplastic obesity. V. Effects of atropine on plasma insulin.

作者信息

Krotkiewski M, Sjöström L, Björntorp P

出版信息

Int J Obes. 1980;4(1):49-56.

PMID:6993387
Abstract

Ten hyperplastic obese women were trained physically on an ad-libitum diet preventing them from losing weight. Plasma-insulin concentrations decreased during oral glucose-tolerance test (OGTT), an effect which was more clearly seen after atropine administration. After intravenous-glucose administration (IVGTT) these effects were absent or much smaller. Insulin secretion stimulated by the sight and smell of food (CIS) was more pronounced after training, this increase being abolished by atropine. Physical training produces vagotony with well-known effects on circulatory variables such as a slower resting heart rate. Both the results after OGTT and CIS show the effects of increased vagotony also on insulin secretion. This effect tends to hide the insulin-concentration-lowering effect of physical training. This consequence of training is possibly dependent on enteric factors associated with insulin secretion since it was not found after IVGTT.

摘要

对10名增生性肥胖女性进行体能训练,她们可随意饮食以防止体重减轻。在口服葡萄糖耐量试验(OGTT)期间,血浆胰岛素浓度下降,阿托品给药后这种效应更明显。静脉注射葡萄糖(IVGTT)后,这些效应不存在或小得多。训练后,食物的视觉和嗅觉刺激(CIS)引起的胰岛素分泌更明显,这种增加被阿托品消除。体能训练会导致迷走神经紧张,对循环变量有众所周知的影响,如静息心率减慢。OGTT和CIS后的结果均表明,迷走神经紧张增加对胰岛素分泌也有影响。这种效应往往掩盖了体能训练降低胰岛素浓度的作用。训练的这种结果可能取决于与胰岛素分泌相关的肠道因素,因为在IVGTT后未发现此现象。

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引用本文的文献

1
Physical training in obese women. Effects of muscle morphology, biochemistry and function.肥胖女性的体育锻炼。对肌肉形态、生物化学及功能的影响。
Eur J Appl Physiol Occup Physiol. 1984;52(4):355-61. doi: 10.1007/BF00943363.
2
The effects of physical training on insulin secretion and effectiveness and on glucose metabolism in obesity and type 2 (non-insulin-dependent) diabetes mellitus.体育锻炼对肥胖及2型(非胰岛素依赖型)糖尿病患者胰岛素分泌、胰岛素效能及葡萄糖代谢的影响。
Diabetologia. 1985 Dec;28(12):881-90. doi: 10.1007/BF00703130.
3
Exercise and obesity.
运动与肥胖
Sports Med. 1986 Mar-Apr;3(2):89-113. doi: 10.2165/00007256-198603020-00002.