Canivet B, Harter M, Viot G, Balarac N, Krebs B P
J Endocrinol Invest. 1980 Apr-Jun;3(2):107-11. doi: 10.1007/BF03348235.
Residual beta cell function was evaluated through circadian determination of C-peptide immunoreactivity (CPR) in eighty insulin-dependent diabetics. Evaluation of beta cell activity through circadian CPR determination was in good agreement with the results obtained by glucagon test which is considered a potent stimulus of C-peptide release. The prevalence of residual beta cell function in our population was 35%. Residual beta cell function was associated with a shorter duration of diabetes, a lower dose of insulin therapy and less chronic complications. On the other hand, serum growth hormone circadian variations were more spread in diabetics without beta cell function. That is consistent with diabetes instability which has been reported more commonly insulin-dependent diabetics without beta cell function.
通过对80例胰岛素依赖型糖尿病患者进行C肽免疫反应性（CPR）的昼夜测定来评估残余β细胞功能。通过昼夜CPR测定来评估β细胞活性，这与通过胰高血糖素试验获得的结果高度一致，胰高血糖素试验被认为是C肽释放的有效刺激因素。我们研究人群中残余β细胞功能的患病率为35%。残余β细胞功能与糖尿病病程较短、胰岛素治疗剂量较低以及慢性并发症较少相关。另一方面，无β细胞功能的糖尿病患者血清生长激素的昼夜变化更为分散。这与糖尿病不稳定性相符，糖尿病不稳定性在无β细胞功能的胰岛素依赖型糖尿病患者中更为常见。
