Murakami E, Hiwada K, Kokubu T
J Endocrinol. 1980 Apr;85(1):151-3. doi: 10.1677/joe.0.0850151.
An isolated rat liver perfusion system was used to study the effects of insulin and glucagon on renin substrate production. Normal livers synthesized renin substrate at a rate of 28.3 +/- 3.8 (S.E.M.) ng angiotensin I equiv./g liver each h (n = 8). The addition of insulin (more than 0.1 i.u.) to the perfusion significantly enhanced the production of renin substrate which was about twofold higher than normal control values (P less than 0.001). However, glucagon (20 micrograms) did not affect the synthesis of renin substrate. These results indicated that insulin promoted the synthesis of renin substrate by the isolated rat liver.
采用离体大鼠肝脏灌注系统研究胰岛素和胰高血糖素对肾素底物生成的影响。正常肝脏每小时合成肾素底物的速率为28.3±3.8（标准误）纳克血管紧张素I当量/克肝脏（n = 8）。向灌注液中加入胰岛素（超过0.1国际单位）可显著增强肾素底物的生成，其生成量比正常对照值高出约两倍（P<0.001）。然而，胰高血糖素（20微克）并不影响肾素底物的合成。这些结果表明胰岛素可促进离体大鼠肝脏合成肾素底物。
