Schriefer J A, Spratto G R
J Pharmacol Methods. 1980 Jun;3(4):297-304. doi: 10.1016/0160-5402(80)90071-6.
Interest in the pharmacological effects of drugs in the elderly has created a need for a laboratory model in which responses of aged animals to drugs can be studied. Dihydrotachysterol (DHT)-induced progeria, a syndrome with symptoms similar to those seen in normal aging, was evaluated as an old age model. DHT-treatment was shown to produce a decreased carbohydrate tolerance that was due to an impaired release of insulin from pancreatic islets and not due to a decreased sensitivity to insulin. These changes were unlike those observed with aging. Thus, DHT-induced progeria would not appear to be a good model for aging for the investigation of carbohydrate metabolism. Evidence is presented which indicates that glucose and tolbutamide act via different mechanism to stimulate insulin release.
对老年人药物药理作用的研究兴趣促使人们需要一个实验室模型，以便能够研究老年动物对药物的反应。二氢速甾醇（DHT）诱导的早衰症是一种症状与正常衰老相似的综合征，被评估为老年模型。研究表明，DHT治疗会导致糖耐量降低，这是由于胰岛胰岛素释放受损，而非对胰岛素的敏感性降低所致。这些变化与衰老过程中观察到的不同。因此，对于碳水化合物代谢的研究而言，DHT诱导的早衰症似乎并非一个良好的衰老模型。有证据表明，葡萄糖和甲苯磺丁脲通过不同机制刺激胰岛素释放。
