Rosen J D, Segall Y, Casida J E
Mutat Res. 1980 Jun;78(2):113-9. doi: 10.1016/0165-1218(80)90090-7.
2-Chloroacrolein, the ultimate mutagen, formed on metabolism of the carcinogenc herbicides, diallate and sulfallate, and its 2-bromo-, 2,3-dichloro- and 2,3,3-trichloro- analogs are much more potent mutagens in the Ames Salmonella typhimurium strain TA1U0 assay than any other aldehydes examined previously or in this study. Polymer formation on reaction of deoxyadenosine with the difunctional 2-chloroacrolein probably involves crosslinking via Schiff base formation at the carbonyl group and Michael addition at the doubts bond.
2-氯丙烯醛是致癌除草剂燕麦敌和草克乐代谢过程中形成的最终诱变剂，其2-溴代、2,3-二氯代和2,3,3-三氯代类似物在鼠伤寒沙门氏菌TA1U0试验中比之前研究或本研究中检测的任何其他醛类都是更强效的诱变剂。脱氧腺苷与双功能的2-氯丙烯醛反应形成聚合物，可能涉及通过羰基处席夫碱的形成和双键处的迈克尔加成进行交联。
