N-羟基氨基甲酸乙酯及其相关化合物在鼠伤寒沙门氏菌中的致突变活性。

The mutagenic activity of ethyl N-hydroxycarbamate and its related compounds in Salmonella typhimurium.

作者信息

Koga H, Kawazoe Y, Tatsumi K, Horiuchi T

出版信息

Mutat Res. 1980 Jun;78(2):145-50. doi: 10.1016/0165-1218(80)90093-2.

Abstract

Alkyl N-hydroxycarbamates exhibited weak but significant mutagenic activity for Salmonella typhimurium TA100. The mutagenic potencies of these N-hydroxycarbamates were ranked thus: ethyl N-hydroxycarbamate greater than propyl N-hydroxycarbamate greater than methyl N-hydroxycarbamate. Acylation of ethyl N-hydroxycarbamate markedly enhanced its mutagenic activity for TA100. The highest mutagenic activity was observed with ethyl N-benzoyloxycarbamate among these acyl derivatives. Almost all the compounds were mutagenic to all the strains TA1535, TA100, TA98, especially to TA100.

摘要

烷基N-羟基氨基甲酸酯对鼠伤寒沙门氏菌TA100表现出微弱但显著的诱变活性。这些N-羟基氨基甲酸酯的诱变效力排序如下：N-羟基氨基甲酸乙酯大于N-羟基氨基甲酸丙酯大于N-羟基氨基甲酸甲酯。N-羟基氨基甲酸乙酯的酰化显著增强了其对TA100的诱变活性。在这些酰基衍生物中，N-苯甲酰氧基氨基甲酸乙酯的诱变活性最高。几乎所有化合物对TA1535、TA100、TA98菌株都有诱变作用，尤其是对TA100。