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小鼠实验性尿路感染中的细菌自发清除:该过程的细胞层面

Spontaneous bacterial clearance in experimental urinary tract infections in mice: cellular aspects of the process.

作者信息

Stadler J, Aronson M, Medalia O, Griffel B

出版信息

Nephron. 1980;25(6):288-92. doi: 10.1159/000181860.

DOI:10.1159/000181860
PMID:6993968
Abstract

The morphological aspects of Proteus mirabilis clearance from the urinary tract of experimentally infected mice were investigated. For this purpose, two groups of mice were compared: a group infected with the bacterium and a group that had just recovered from the infection. Differences between the two groups were found in extent of bladder and kidney inflammation, depth of infiltration into the bladder wall, and in the increment of bladder volume. There was no clear-cut difference between the two groups in number of lymphocytes and monocytes, but the number of granulocytes was significantly lower in the bladder and kidneys of the recently healed animals. Likewise, the plasma cells were fewer in healed animals than in infected ones, the difference being statistically significant for bladders and on the verge of significance for kidneys.

摘要

对实验感染小鼠尿道中奇异变形杆菌清除的形态学方面进行了研究。为此,比较了两组小鼠:一组感染了该细菌,另一组刚从感染中恢复。两组在膀胱和肾脏炎症程度、膀胱壁浸润深度以及膀胱体积增加方面存在差异。两组在淋巴细胞和单核细胞数量上没有明显差异,但在刚愈合动物的膀胱和肾脏中粒细胞数量显著更低。同样,愈合动物中的浆细胞比感染动物中的少,膀胱中的差异具有统计学意义,肾脏中的差异接近具有统计学意义。

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引用本文的文献

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Interaction of Escherichia coli with polymorphonuclear leukocytes in pathogenesis of urinary tract infection in mice.小鼠尿路感染发病机制中大肠杆菌与多形核白细胞的相互作用
Infect Immun. 1988 Apr;56(4):947-53. doi: 10.1128/iai.56.4.947-953.1988.