Etiological considerations in Gordon's syndrome: possible role of prostaglandins.

The syndrome of hypertension, low plasma renin and aldosterone and hyperchloraemic acidosis (Gordon's syndrome) may be caused by a switch in the intrarenal synthesis of prostaglandins from PGE2 to PGF2 which results in changes in the renin-angiotensin and in the kallikrein-kinin systems. The role of excess reabsorption of sodium chloride and hypersensitivity of the vasculature to angiotensin II in the genesis of the high blood pressure and of the other metabolic disturbances is discussed.