Kotchen T A, Krzyzaniak K E, Anderson J E, Ernst C B, Galla J H, Luke R G
Am J Physiol. 1980 Jul;239(1):F44-9. doi: 10.1152/ajprenal.1980.239.1.F44.
To determine if inhibition of renin release by HCl is related to acidosis or to Cl-, the effects of peripheral venous infusions of HCl and H2SO4 on plasma renin activity (PRA) were compared in the dog and the rat. In NaCl-deprived, pentobarbital-anesthetized dogs, either 0.15 M HCl (n = 10) or 0.075 M H2SO4 (n = 7) was infused for 60 min. In 5 of the 10 HCl-infused dogs (group A), urine Cl- excretion increased (P less than 0.01) during HCl infusion. In the remaining five dogs (group B), Cl- excretion did not increase. Cl- excretion also did not increase during H2SO4 infusion. Comparable acidosis was produced in all three groups. PRA decreased (P less than 0.01) in response to HCl in group A but did not change (P greater than 0.8) in group B HCl-infused dogs or in H2SO4-infused dogs. In NaCl-deprived, anesthetized rats, PRA was suppressed (P less than 0.05) by HCl (from 40.6 +/- 9.4 to 27.4 +/- 5.3 ng . ml-1 . h-1 (SE)) but not H2SO4 (from 37.1 +/- 4.2 to 37.0 +/- 6.3 ng . ml-1 . h-1), despite comparable acidosis. Cl- excretion increased only in HCl-infused rats. In conclusion, inhibition of PRA by acute infusion of HCl is specifically related to Cl-.
为了确定盐酸对肾素释放的抑制作用是与酸中毒还是与氯离子有关，在犬和大鼠中比较了外周静脉输注盐酸和硫酸对血浆肾素活性（PRA）的影响。在剥夺氯化钠、戊巴比妥麻醉的犬中，输注0.15M盐酸（n = 10）或0.075M硫酸（n = 7）60分钟。在10只输注盐酸的犬中，有5只（A组）在输注盐酸期间尿氯排泄增加（P<0.01）。其余5只犬（B组）氯排泄未增加。输注硫酸期间氯排泄也未增加。所有三组均产生了相当程度的酸中毒。A组中盐酸使PRA降低（P<0.01），但B组输注盐酸的犬或输注硫酸的犬中PRA未改变（P>0.8）。在剥夺氯化钠、麻醉的大鼠中，盐酸使PRA受到抑制（P<0.05）（从40.6±9.4降至27.4±5.3 ng·ml-1·h-1（SE）），但硫酸未使其受抑制（从37.1±4.2降至37.0±6.3 ng·ml-1·h-1），尽管酸中毒程度相当。仅在输注盐酸的大鼠中氯排泄增加。总之，急性输注盐酸对PRA的抑制作用与氯离子有特异性关系。
