Lingappa V R, Lingappa J R, Blobel G
Ann N Y Acad Sci. 1980;343:356-61. doi: 10.1111/j.1749-6632.1980.tb47264.x.
Signal sequences for the transfer of proteins across membranes are usually found at the NH2-terminus of nascent secretory and transmembrane proteins. The functionally equivalent signal sequence of chicken ovalbumin however, is localized in the middle of the molecule. The implication of this surprising finding for biogenesis of membrane proteins is discussed.
