胍法辛的门诊试验。
An ambulatory trial of guanfacine.
作者信息
Mann S, Millar Craig M W, Melville D I, Cashman P M, Raftery E B
出版信息
Br J Clin Pharmacol. 1980;10 Suppl 1(Suppl 1):103S-107S. doi: 10.1111/j.1365-2125.1980.tb04915.x.
Abstract
- The effects of acute and long-term treatment with guanfacine on ambulatory BP were studied. 2. The first day of therapy with guanfacine 1 mg produced a small reduction in BP whereas chronic therapy with doses up to 6 mg given once daily produced a substantial smooth reduction throughout the whole 24 hours. 3. There were no noticeable symptoms or rebound effects on withdrawal of the drug; side-effects, were, however, prominent during therapy. 4. The drug reduced BP during dynamic exercise but did little during isometric exercise; no postural hypotension was noted during tilting.
摘要
- 研究了胍法辛急性和长期治疗对动态血压的影响。2. 胍法辛1毫克治疗的第一天血压有小幅下降，而每日一次给予高达6毫克剂量的长期治疗在整个24小时内使血压显著平稳下降。3. 停药时没有明显症状或反跳效应；然而，治疗期间副作用明显。4. 该药物在动态运动期间降低血压，但在等长运动期间作用不大；倾斜期间未观察到体位性低血压。
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Rebound phenomenon during gradual withdrawal of clonidine.可乐定逐渐撤药期间的反跳现象。
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Antihypertensive effect of N-amidino-2-(2,6-dichlorophenyl) acetamide hydrochloride. A double-blind cross-over trial versus clonidine.
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New system for recording ambulatory blood pressure in man.人体动态血压记录新系统。
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Pharmacology of BS 100-141, a centrally acting antihypertensive drug.中枢性抗高血压药物BS 100 - 141的药理学
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Circadian variation of blood-pressure.血压的昼夜变化
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