Meffin P J, Winkle R A, Peters F A, Harrison D C
Clin Pharmacol Ther. 1978 Nov;24(5):542-7. doi: 10.1002/cpt1978245542.
The relationship between dose and area under the blood concentration-time curve has been studied in 6 healthy subjects following both oral and intravenous doses of acebutolol. There is a more than proportional increase in area with increasing oral doses, and the area over a dosing interval following multiple oral doses is greater than the total area after a single dose of the same size. The role of an acetyl metabolite in producing these effects is discussed, as is the relevance of these observations to the clinical use of acebutolol.
在6名健康受试者中，研究了醋丁洛尔口服和静脉给药后的剂量与血药浓度-时间曲线下面积之间的关系。随着口服剂量增加，曲线下面积呈超比例增加，多次口服给药后一个给药间隔内的曲线下面积大于相同剂量单次给药后的总面积。文中讨论了乙酰代谢产物在产生这些效应中的作用，以及这些观察结果与醋丁洛尔临床应用的相关性。
