Godbillon J, Gerardin A, John V A, Theobald W
Eur J Clin Pharmacol. 1983;24(5):655-60. doi: 10.1007/BF00542217.
A potential pharmacokinetic interaction between the beta-blocking drug, metoprolol, and the diuretic, chlorthalidone, has been investigated in three single or multiple dose studies in healthy volunteers. The pharmacokinetic profile of metoprolol 100 mg was not affected by pretreatment with or co-administration of chlorthalidone 25 mg twice daily. Similarly, the pre-dosing steady-state level of chlorthalidone during chronic treatment and its blood level profile after a single 25 mg dose were not affected by metoprolol. The bioavailabilities of the 2 drugs administered in combination were identical to those observed when each drug was administered alone. These studies demonstrate that there is no pharmacokinetic interaction between metoprolol and chlorthalidone when doses of 100 and 25 mg, respectively, are co-administered twice daily.
在三项针对健康志愿者的单剂量或多剂量研究中，对β受体阻滞剂美托洛尔和利尿剂氯噻酮之间潜在的药代动力学相互作用进行了研究。每日两次服用25mg氯噻酮进行预处理或联合给药，均未影响100mg美托洛尔的药代动力学特征。同样，美托洛尔也未影响氯噻酮在长期治疗期间的给药前稳态水平及其单次服用25mg剂量后的血药浓度曲线。联合使用这两种药物时的生物利用度与单独使用每种药物时观察到的生物利用度相同。这些研究表明，当分别每日两次联合服用100mg美托洛尔和25mg氯噻酮时，二者之间不存在药代动力学相互作用。
