Clarkson A R, Seymour A E, Woodroffe A J, McKenzie P E, Chan Y L, Wootton A M
Clin Nephrol. 1980 May;13(5):215-8.
IgA nephropathy, a condition thought to cause slowly progressive renal damage, is frequently associated with high serum IgA levels. As phenytoin sodium lowers serum IgA concentrations, a controlled trial of therapy with this drug was conducted over a two-year period in patients with IgA nephropathy. Despite significant depression of serum IgA concentrations in the treatment group, there was no significant change in any other clinical, biochemical or pathological parameter, in either control or treatment groups. Indeed, there was evidence for a slow progression of renal damage in both groups. These observations suggest that the elevated serum IgA concentrations in IgA nephropathy are not of primary pahtogenetic significance but are rather a consequence of a basic abnormality in antigen processing and IgA production.
IgA肾病被认为会导致缓慢进展的肾脏损害，常与血清IgA水平升高有关。由于苯妥英钠可降低血清IgA浓度，因此对IgA肾病患者进行了为期两年的该药物治疗对照试验。尽管治疗组血清IgA浓度显著降低，但对照组和治疗组的任何其他临床、生化或病理参数均无显著变化。事实上，两组均有肾脏损害缓慢进展的证据。这些观察结果表明，IgA肾病中血清IgA浓度升高并非主要的致病因素，而是抗原处理和IgA产生基本异常的结果。
