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麻醉状态下自发性高血压大鼠的心输出量分布

The distribution of cardiac output in the anaesthetized spontaneously hypertensive rat.

作者信息

Hilley C R, Yates M S

出版信息

Clin Sci Mol Med. 1978 Sep;55(3):317-20. doi: 10.1042/cs0550317.

DOI:10.1042/cs0550317
PMID:699508
Abstract
  1. Radioactive 15 micrometer and 50 micrometer diameter microspheres were used to determine cardiac output, its regional distribution and tissue blood flow in adult normotensive Wistar and Okamoto spontaneously hypertensive rats. 2. Cardiac output in the spontaneously hypertensive rats was the same as in Wistar normotensive rats, but its distribution in the hypertensive rats appeared to differ: there was a significant increase in the proportion of microspheres trapped in the liver whereas fewer were found in the gastrointestinal tract. This indicates that a greater fraction of the cardiac output passes along the hepatic artery and less through the splanchnic bed. 3. Blood flow in skin and skeletal muscle in spontaneously hypertensive rats was approximately 50% of that in Wistar normotensive rats.
摘要
  1. 使用直径为15微米和50微米的放射性微球来测定成年正常血压的Wistar大鼠和冈本自发性高血压大鼠的心输出量、其区域分布以及组织血流量。2. 自发性高血压大鼠的心输出量与Wistar正常血压大鼠相同,但其分布在高血压大鼠中似乎有所不同:滞留在肝脏中的微球比例显著增加,而在胃肠道中发现的微球较少。这表明心输出量的更大一部分沿着肝动脉流动,而通过内脏床的较少。3. 自发性高血压大鼠皮肤和骨骼肌的血流量约为Wistar正常血压大鼠的50%。

相似文献

1
The distribution of cardiac output in the anaesthetized spontaneously hypertensive rat.麻醉状态下自发性高血压大鼠的心输出量分布
Clin Sci Mol Med. 1978 Sep;55(3):317-20. doi: 10.1042/cs0550317.
2
Measurement of cardiac output and its distribution in rats under various sodium intakes, using 15 and 10 micron spheres.使用15微米和10微米的微球测量不同钠摄入量大鼠的心输出量及其分布。
Cardiovasc Res. 1980 Oct;14(10):577-81. doi: 10.1093/cvr/14.10.577.
3
Regional blood flow in normotensive and spontaneously hypertensive rats.
Am J Physiol. 1976 Mar;230(3):691-8. doi: 10.1152/ajplegacy.1976.230.3.691.
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Systemic and regional haemodynamics in anterior hypothalamic hypertension in spontaneously hypertensive and Wistar-Kyoto rats.自发性高血压大鼠和Wistar-Kyoto大鼠下丘脑前部高血压中的全身和局部血流动力学
Clin Sci (Lond). 1980 Dec;59 Suppl 6:251s-253s. doi: 10.1042/cs059251s.
5
[Effect of dopamine, histamine and acetylcholine on the distribution of cardiac output in the anesthetized rat (author's transl)].多巴胺、组胺和乙酰胆碱对麻醉大鼠心输出量分布的影响(作者译)
J Physiol (Paris). 1977;73(8):1081-8.
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Distribution of cardiac output in different models of hypertension in the conscious rat.
Pflugers Arch. 1979 Mar 16;379(2):219-22. doi: 10.1007/BF00586952.
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Impairment on cardiac output and blood flow adjustments to exercise in L-NAME-induced hypertensive rats.L-精氨酸甲酯(L-NAME)诱导的高血压大鼠运动时的心输出量及血流调节受损。
J Cardiovasc Pharmacol. 2006 Mar;47(3):371-6. doi: 10.1097/01.fjc.0000210068.70076.e2.
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Regional blood flows measured in conscious rats by combined Fick and microsphere methods.通过菲克法和微球法相结合的方式在清醒大鼠身上测量局部血流量。
Am J Physiol. 1978 Sep;235(3):H357-60. doi: 10.1152/ajpheart.1978.235.3.H357.
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Regional vascular resistance and haemodynamics in the spontaneously hypertensive rat: the effects of bradykinin.自发性高血压大鼠的局部血管阻力和血流动力学:缓激肽的作用。
J Cardiovasc Pharmacol. 1990 Feb;15(2):211-7. doi: 10.1097/00005344-199002000-00006.
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Effects of intravenous diltiazem on cardiocirculatory dynamics and cardiac output distribution in conscious spontaneously hypertensive rats.静脉注射地尔硫䓬对清醒自发性高血压大鼠心脏循环动力学和心输出量分布的影响。
J Cardiovasc Pharmacol. 1986 Mar-Apr;8(2):241-51. doi: 10.1097/00005344-198603000-00004.

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