Levitt N S, Vinik A I, Child P T
J Clin Endocrinol Metab. 1980 Aug;51(2):254-8. doi: 10.1210/jcem-51-2-254.
Glucose-dependent insulin-releasing peptide or gastric inhibitory polypeptide (GIP) is released into the circulation after ingestion of a mixed meal and is thought to enhance glucose-induced insulin release. We investigated basal and meal-stimulated GIP secretion in noninsulin-dependent maturity-onset diabetics (MODs). Twelve MODs and 12 healthy normal subjects were studied. Mean (+/- SE) basal plasma GIP concentrations were similar in MODs (297 +/- 34.5 pg/ml) and healthy subjects (305 +/- 29.7 pg/ml). Overnight insulin infusion normalized basal glucose levels in the MODs and induced a slight but insignificant rise in plasma GIP levels in MODs to 362 +/- 40.9 pg/ml; overnight gastric aspiration caused a further slight rise in basal GIP concentration to 392 +/- 56.6 pg/ml. The GIP responses to a mixed meal were significantly impaired at 90-240 min in MODs. The MODs were divided into 2 groups, each with 6 subjects: 1 group with autonomic neuropathy (AN) and the other without. The GIP responses in MODs without AN were similar to those in healthy subjects, but were significantly reduced in MODs with AN at all times after the meal. We suggest that the release of GIP after a meal is dependent upon the integrity of the autonomic nervous system; the mechanism may be related to the loss of autonomic control of gastric emptying or dependence of GIP secretion on autonomic modulation.
葡萄糖依赖性促胰岛素释放肽或胃抑制性多肽（GIP）在摄入混合餐后释放入循环系统，被认为可增强葡萄糖诱导的胰岛素释放。我们研究了非胰岛素依赖型成年发病型糖尿病患者（MODs）的基础及餐后刺激下的GIP分泌情况。研究了12名MODs患者和12名健康正常受试者。MODs患者（297±34.5 pg/ml）和健康受试者（305±29.7 pg/ml）的平均（±SE）基础血浆GIP浓度相似。夜间胰岛素输注使MODs患者的基础血糖水平正常化，并使MODs患者的血浆GIP水平轻微但无显著升高至362±40.9 pg/ml；夜间胃抽吸使基础GIP浓度进一步轻微升高至392±56.6 pg/ml。MODs患者在90 - 240分钟时对混合餐的GIP反应显著受损。将MODs患者分为2组，每组6名受试者：1组有自主神经病变（AN），另一组没有。无AN的MODs患者的GIP反应与健康受试者相似，但有AN的MODs患者在餐后所有时间的GIP反应均显著降低。我们认为餐后GIP的释放取决于自主神经系统的完整性；其机制可能与胃排空自主控制的丧失或GIP分泌对自主调节的依赖性有关。
