Mattox D E
Otolaryngol Head Neck Surg (1979). 1980 Mar-Apr;88(2):111-3. doi: 10.1177/019459988008800201.
A hurdle in the evaluation of any therapy of ISHL has previously been proposed-a spontaneous recovery of satisfactory hearing of 63% of patients. The hurdle has yet to be convincingly passed by any drug therapy. The intent here is not to denigrate the use of drugs in this syndrome; on the contrary, it remains likely that some subgroups of ISHL would benefit from specific medical management. For instance, a systemic viremia would be most logically treated with anti-inflammatory agents and a thrombotic event with anticoagulants. However, prospective studies in which patients are divided into prognostic categories before treatment with adequate control groups must be performed.
此前曾有人提出，评估突发性听力损失（ISHL）任何治疗方法时存在一个障碍——63%的患者听力能自发恢复到令人满意的程度。任何药物治疗都尚未令人信服地跨越这一障碍。这里的目的并非诋毁在该综合征中使用药物；相反，突发性听力损失的某些亚组很可能会从特定的药物治疗中获益。例如，全身性病毒血症最合理的治疗方法是使用抗炎药，血栓形成事件则使用抗凝剂。然而，必须进行前瞻性研究，在治疗前将患者分为不同的预后类别，并设置适当的对照组。
