Irons G B, Olson R M
Plast Reconstr Surg. 1980 Aug;66(2):199-203. doi: 10.1097/00006534-198008000-00003.
Aplasia cutis congenita is an uncommon condition; fewer than 300 cases have been reported in the literature. Usually, the condition occurs as a focal scalp ulcer, but it may involve the full thickness of the skull or other areas of the body. Most lesions require coverage with a scalp flap, though only observation or split-thickness skin grafts may be adequate for smaller lesions. Four cases have been presented, representing a spectrum of therapeutic requirements from simple observation to emergency intervention to control life-threatening hemorrhage. The case of aplasia cutis congenita of the upper arm may represent a persistence of prenatal focal ischemia that has proved to be resistant to numerous attempts of split-thickness skin grafting.
先天性皮肤发育不全是一种罕见病症；文献报道的病例少于300例。通常，该病表现为头皮局灶性溃疡，但也可能累及颅骨全层或身体其他部位。多数皮损需要用头皮瓣覆盖，不过较小的皮损仅观察或采用刃厚皮片移植可能就足够了。本文介绍了4例病例，代表了从单纯观察到紧急干预以控制危及生命的出血等一系列治疗需求。上臂先天性皮肤发育不全的病例可能代表产前局灶性缺血持续存在，事实证明，多次刃厚皮片移植尝试均对其无效。
