Gonvers J J, Loup P, Hofstetter J R, Brunner H R
Schweiz Med Wochenschr. 1980 May 31;110(22):869-71.
Plasma renin activity and plasma aldosterone have been measured in 31 patients in different clinical stages of alcoholic cirrhosis. Plasma renin activity and plasma aldosterone were within the normal range in patients with compensated cirrhosis and in patients with untreated cirrhosis and ascites. These results are not in keeping with the traditional concepts of reduced "effective' blood volume with stimulation of the renin-angiotensin system. In ascites treated with diuretics, and in the hepato-renal syndrome, the renin-angiotensin system was, however, stimulated. Peritoneo-venous shunt was followed by suppression of this stimulation.
对31例处于不同临床阶段的酒精性肝硬化患者测定了血浆肾素活性和血浆醛固酮。在代偿期肝硬化患者以及未经治疗的肝硬化腹水患者中,血浆肾素活性和血浆醛固酮均在正常范围内。这些结果与传统观念中“有效”血容量减少并刺激肾素-血管紧张素系统的观点不一致。然而,在使用利尿剂治疗腹水的患者以及肝肾综合征患者中,肾素-血管紧张素系统受到了刺激。腹腔-静脉分流术后,这种刺激作用受到抑制。