Kaspar L
Wien Klin Wochenschr. 1980 Apr 11;92(8):276-9.
Since diabetics frequently suffer from urinary tract infections which can be successfully treated with a combination of sulphonamide derivatives and the bacteriocide trimethoprim, the question of possible interactions between such agents and diabetic therapy is of interest. A double-blind crossover trial was, therefore, carried out in 10 diabetics who were being treated with insulin, and 10 who were under treatment with sulphonylurea derivatives. Sulfametrol was administered in combination with trimethoprim (= Lidaprim). The blood glucose level was determined 3 times daily. No tendency towards hypoglycaemia was observed under treatment with the active agent in either group of patients. Within 5 days creatinine and blood urea nitrogen had increased to pathological levels in those patients who showed previous renal damage. It is concluded that the lack of interaction of these drugs with diabetes therapy justifies the use of these chemotherapeutic agents in diabetics. They are effective and relatively inexpensive in comparison with other agents. Subjective tolerance is also good.
由于糖尿病患者经常遭受尿路感染，而磺胺类衍生物与杀菌剂甲氧苄啶联合使用可成功治疗尿路感染，因此这些药物与糖尿病治疗之间可能存在相互作用的问题备受关注。因此，对10名接受胰岛素治疗的糖尿病患者和10名接受磺酰脲类衍生物治疗的患者进行了一项双盲交叉试验。磺胺美曲与甲氧苄啶（=利达普明）联合给药。每天测定3次血糖水平。两组患者在使用活性剂治疗期间均未观察到低血糖倾向。在那些先前有肾损伤的患者中，肌酐和血尿素氮在5天内升至病理水平。得出的结论是，这些药物与糖尿病治疗之间缺乏相互作用证明在糖尿病患者中使用这些化疗药物是合理的。与其他药物相比，它们有效且相对便宜。主观耐受性也良好。
