Russanov E, Leutchev S, Balevska P
Acta Physiol Pharmacol Bulg. 1980;6(1):48-52.
It is established that the hexobarbital oxidase activity of 12,000 g rat liver supernatant does not change when examined at the 2nd h after whole body irradiation (700 R) but increases at longer postexposure periods (72 hours). Intraperitoneal injection of phenobarbital in daily doses of 80 mg/kg body wt for three days increases the hexobarbital oxidase activity of non-irradiated rats, the effect being much stronger in phenobarbital-treated rats at the 2nd h of postirradiation. The possible mechanisms of these effects are discussed, as well as their correlation with the increased lipid peroxidation and their significance for the radiation effect on the drug action.
已经确定，当在全身照射（700伦琴）后第2小时进行检测时，12,000克大鼠肝脏上清液的己巴比妥氧化酶活性没有变化，但在照射后更长时间（72小时）会增加。以每天80毫克/千克体重的剂量腹腔注射苯巴比妥，连续三天，可增加未受照射大鼠的己巴比妥氧化酶活性，在照射后第2小时，这种作用在接受苯巴比妥治疗的大鼠中更强。讨论了这些作用的可能机制，以及它们与脂质过氧化增加的相关性，以及它们对药物作用的辐射效应的意义。
