Argyris T S, Miller A
Anat Rec. 1976 Aug;185(4):447-51. doi: 10.1002/ar.1091850406.
In contrast to multiple injections of phenobarbital, a single injection of 50 mg/kg body wt of phenobarbital into immature male rats results, after a transient increase in hepatocyte mitotic activity, in a marked decrease in hepatocyte mitotic activity to below control levels by day 3, followed by a return to control levels by day 5. This unusual pattern of hepatocyte mitotic activity can be called fourth again by a second injection of 50 mg phenobarbital/kg body wt. However, a single injection of 50 mg/kg body wt of phenobarbital into immature male rats results in a pattern of change of liver wet weight, protein, and aminopyrine demethylase activity which is similar to that observed after multiple injections of phenobarbital, except that the changes are smaller in magnitude. Liver wet weight, protein, and aminopyrine demethylase activity increase and reach a peak within two days after phenobarbital injection, and then they return to control levels by five days. The same pattern of change in liver wet weight, protein, and aminopyrine demethylase activity can be elicited again by a second injection of 50 mg phenobarbital/kg body wt.
与多次注射苯巴比妥不同，向未成熟雄性大鼠单次注射50mg/kg体重的苯巴比妥后，在肝细胞有丝分裂活性短暂增加后，到第3天肝细胞有丝分裂活性显著降低至对照水平以下，随后在第5天恢复到对照水平。第二次注射50mg苯巴比妥/kg体重可再次使这种肝细胞有丝分裂活性的异常模式出现。然而，向未成熟雄性大鼠单次注射50mg/kg体重的苯巴比妥会导致肝脏湿重、蛋白质和氨基比林脱甲基酶活性的变化模式，这与多次注射苯巴比妥后观察到的相似，只是变化幅度较小。苯巴比妥注射后两天内，肝脏湿重、蛋白质和氨基比林脱甲基酶活性增加并达到峰值，然后在五天内恢复到对照水平。第二次注射50mg苯巴比妥/kg体重可再次引发肝脏湿重、蛋白质和氨基比林脱甲基酶活性的相同变化模式。
