Federman J, Whitford J A, Anderson S T, Pitt A
Aust N Z J Med. 1980 Jun;10(3):289-94. doi: 10.1111/j.1445-5994.1980.tb04072.x.
Fifty-five patients with recent acute myocardial infarction entered a single-blind cross-over trial to assess the effect of oral practolol 200 mg twice daily on the incidence and nature of ventricular arrhythmias in the first year following myocardial infarction. Patients had 24-hour Holter electrocardiogram tape monitoring at two weeks following infarction and at three-monthly intervals for one year. Twenty-six patients completed the full year of the trial with 12% of tape recordings technically unsatisfactory. A total of 46 periods of comparison of the action of practolol versus placebo therapy were available in thirty patients. Whilst receiving the selective beta adrenergic blocking agent, practolol, there was a significant reduction in the percentage of studied hours during which salvos of ventricular premature beats occurred (P < 0.025), however the percentage of patients in whom salvos were recorded was unchanged. The incidence of all other ventricular arrhythmias was not reduced in the practolol group. When the effect of practolol was related to the site of infarction, anterior or inferior, there was no significant reduction in the incidence of ventricular arrhythmias.
55例近期发生急性心肌梗死的患者进入一项单盲交叉试验，以评估每日两次口服200 mg心得宁对心肌梗死后第一年室性心律失常的发生率及性质的影响。患者在心肌梗死后两周以及之后一年每三个月进行一次24小时动态心电图监测。26例患者完成了为期一年的试验，其中12%的记录在技术上不合格。30例患者共有46个心得宁与安慰剂治疗作用对比期。在接受选择性β肾上腺素能阻滞剂心得宁治疗期间，室性早搏连发出现的研究小时数百分比显著降低（P<0.025），然而记录到室性早搏连发的患者百分比未变。心得宁组所有其他室性心律失常的发生率并未降低。当将心得宁的作用与梗死部位（前壁或下壁）相关联时，室性心律失常的发生率并未显著降低。
