Allen J D, Pantridge J F, Shanks R G
Am J Med. 1975 Feb;58(2):199-208. doi: 10.1016/0002-9343(75)90570-7.
The cardioselective beta-adrenoceptor blocking agent practolol was used in the management of ventricular and supraventricular dysrhythmias associated with acute myocardial infarction in 134 patients, and in the management of these dysrhythmias in 19 atients with acute myocardial ischemia. Practolol was frequently effective in controlling ventricular dysrhythmias which occurred within the first 24 hours after the onset of symptoms of acute myocardial infarction. It was also effective in controlling the ventricular dysrhythmias which occurred after resuscitation from ventricular fibrillation. It was of particular value when therapeutic doses of lidocaine had been ineffective. Practolol was much less effective in controlling ventricular dysrhythmias which occurred more than 24 hours after acute infarction. Atrial fibrillation and atrial flutter were infrequently abolished by practolol in undigitalized patients after acute myocardial infarction. There was no correlation between the effectiveness of practolol and the blood concentration of the drug. One adverse effect of practolol was the occurence of sinus bradycardia with or without an increase in the frequency of ventricular ectopic beats. Bradycardia was sometimes accompanied by hypotension. Severe hypotension occasionally occurred in the absence of bradycardia.
心脏选择性β肾上腺素能受体阻滞剂心得宁用于134例急性心肌梗死伴发的室性和室上性心律失常的治疗，以及19例急性心肌缺血患者这些心律失常的治疗。心得宁在控制急性心肌梗死症状出现后头24小时内发生的室性心律失常方面常常有效。它在控制心室颤动复苏后发生的室性心律失常方面也有效。当治疗剂量的利多卡因无效时，心得宁具有特殊价值。心得宁在控制急性梗死后24小时以上发生的室性心律失常方面效果要差得多。急性心肌梗死后，心得宁很少能消除未用洋地黄化患者的心房颤动和心房扑动。心得宁的疗效与药物血浓度之间没有相关性。心得宁的一个不良反应是出现窦性心动过缓，伴有或不伴有室性早搏频率增加。心动过缓有时伴有低血压。严重低血压偶尔在无心动过缓时发生。
