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膀胱输尿管反流会导致同种异体肾移植失败吗?

Does vesicoureteric reflux result in renal allograft failure?

作者信息

McMorrow R G, Curtis J J, Lucas B A, Williams C, McRoberts J W, Luke R G

出版信息

Clin Nephrol. 1980 Aug;14(2):89-91.

PMID:6996880
Abstract

Vesicoureteric reflux (VUR) into transplanted kidneys has been cited as an often disregarded but frequent complication of transplantation which is associated with a glomerular lesion that resembles membranoproliferative glomerulonephritis, marked proteinuria, and graft failure. To determine the prevalence of this complication in our transplant population, all of our 23 patients with marked proteinuria and 27 controls without proteinuria had voiding cystourethrograms performed approximately two years after transplantation. In our population, VUR was infrequent (8%). Moreover, in the three of the four cases detected renal function has not deteriorated and three of the four do not have marked proteinuria. We cannot confirm the suggestion that VUR is a frequent cause of late renal allograft failure.

摘要

移植肾的膀胱输尿管反流(VUR)被认为是一种常被忽视但很常见的移植并发症,它与一种类似于膜增生性肾小球肾炎的肾小球病变、明显蛋白尿和移植肾失功有关。为了确定这一并发症在我们移植人群中的发生率,我们对所有23例有明显蛋白尿的患者和27例无蛋白尿的对照者在移植后约两年进行了排尿膀胱尿道造影。在我们的人群中,VUR并不常见(8%)。此外,在检测出的4例病例中,有3例肾功能未恶化,4例中有3例没有明显蛋白尿。我们无法证实VUR是同种异体肾移植晚期失功的常见原因这一观点。

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