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Cyclophosphamide cardiotoxicity.

作者信息

von Bernuth G, Adam D, Hofstetter R, Lang D, Mohr W, Kohne E, Niethammer D

出版信息

Eur J Pediatr. 1980 Jun;134(1):87-90. doi: 10.1007/BF00442410.

DOI:10.1007/BF00442410
PMID:6997053
Abstract

A 12-year-old boy with aplastic anemia developed severe but reversible cardiac failure after treatment with 200 mg/kg cyclophosphamide (4 x 50 mg/kg on four consecutive days) given as preparation for bone marrow grafting. This and previously reported cases demonstrate the possibility of cardiotoxicity after high doses of the drug.

摘要

相似文献

1
Cyclophosphamide cardiotoxicity.
Eur J Pediatr. 1980 Jun;134(1):87-90. doi: 10.1007/BF00442410.
2
Cyclophosphamide cardiotoxicity: an analysis of dosing as a risk factor.环磷酰胺的心脏毒性：作为风险因素的剂量分析
Blood. 1986 Nov;68(5):1114-8.
3
Recovery from aplastic anemia following attempted marrow transplantation.尝试进行骨髓移植后再生障碍性贫血的恢复情况。
Exp Hematol. 1976 Mar;4(2):97-102.
4
Durable treatment-free remission after high-dose cyclophosphamide therapy for previously untreated severe aplastic anemia.高剂量环磷酰胺治疗初治重型再生障碍性贫血后持久的无治疗缓解
Ann Intern Med. 2001 Oct 2;135(7):477-83. doi: 10.7326/0003-4819-135-7-200110020-00006.
5
High-dose cyclophosphamide in aplastic anaemia.
Lancet. 2001 Apr 7;357(9262):1128-9. doi: 10.1016/S0140-6736(00)04278-1.
6
Bone marrow transplantation for aplastic anemia. Establishment of chimerism using multiple HL-A identical donors following pretreatment with cyclophosphamide.再生障碍性贫血的骨髓移植。使用环磷酰胺预处理后，采用多个HL-A全相合供体建立嵌合体。
Transplantation. 1971 Jun;11(6):573-5.
7
Cyclophosphamide-induced cardiomyopathy during bone marrow transplantation for severe aplastic anemia.重型再生障碍性贫血骨髓移植期间环磷酰胺诱导的心肌病
J Assoc Physicians India. 1994 Feb;42(2):159-60.
8
Autologous marrow recovery following allogeneic marrow transplantation in a patient with severe aplastic anemia.一名重型再生障碍性贫血患者接受异基因骨髓移植后的自体骨髓恢复情况。
Exp Hematol. 1976 May;4(3):131-7.
9
[Transplantation of bone marrow selected by HL-A and MLC-antigens into a patient with aplastic anemia].[将经HL - A和混合淋巴细胞培养抗原筛选的骨髓移植给一名再生障碍性贫血患者]
Probl Gematol Pereliv Krovi. 1975 Dec;20(12):28-32.
10
Successful pregnancy after high dose chemotherapy and marrow transplantation for treatment of aplastic anemia.大剂量化疗和骨髓移植治疗再生障碍性贫血后成功妊娠。
Exp Hematol. 1980 Jan;8(1):57-60.

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Bone marrow transplantation may augment cardiac systolic function in patients with a reduced left ventricular ejection fraction.骨髓移植可能增强左心室射血分数降低患者的心脏收缩功能。
J Cardiovasc Dis Res. 2012 Oct;3(4):310-4. doi: 10.4103/0975-3583.102713.
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Minimising the long-term adverse effects of childhood leukaemia therapy.

本文引用的文献

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Cyclophosphamide regimens in rhesus monkey with and without marrow infusion.恒河猴接受和未接受骨髓输注时的环磷酰胺治疗方案。
Cancer Res. 1970 Aug;30(8):2195-203.
2
Cardiac and pulmonary effects of high doses of cyclophosphamide and isophosphamide.高剂量环磷酰胺和异环磷酰胺对心脏和肺部的影响。
Cancer Res. 1974 Jul;34(7):1586-91.
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Cancer Chemother Rep. 1974 Sep-Oct;58(5 Pt 1):709-14.
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Myocardial diseases of animals.动物的心肌疾病
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Intermittent high-dose cyclophosphamide (NSC-26271) treatment of stage III ovarian carcinoma.
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Marrow transplanation in man following cyclophosphamide.环磷酰胺治疗后人类的骨髓移植
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The pathology of bone marrow transplantation.骨髓移植的病理学
Pathol Annu. 1974;9(0):291-344.
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Allogeneic marrow grafting for treatment of aplastic anemia.
Blood. 1974 Feb;43(2):157-80.
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Aplastic anemia treated by marrow transplantation.通过骨髓移植治疗的再生障碍性贫血。
Transplant Proc. 1973 Mar;5(1):913-6.
9
Cardiac pathologic findings in patients treated with bone marrow transplantation.接受骨髓移植治疗患者的心脏病理检查结果
Hum Pathol. 1976 Jan;7(1):17-45. doi: 10.1016/s0046-8177(76)80004-4.
10
Acute lethal carditis caused by high-dose combination chemotherapy. A unique clinical and pathological entity.高剂量联合化疗引起的急性致死性心肌炎。一种独特的临床和病理实体。
Lancet. 1976 Jan 10;1(7950):58-62. doi: 10.1016/s0140-6736(76)90151-3.