Thomas E D, Storb R, Giblett E R, Longpre B, Weiden P L, Fefer A, Witherspoon R, Clift R A, Buckner C D
Exp Hematol. 1976 Mar;4(2):97-102.
A 23-year-old man with severe idiopathic aplastic anemia was prepared for marrow transplantation by the administration of cyclophosphamide (CY) 50 mg/kg on each of 4 days. He then received an intravenous infusion of 9.5 x 10(9) marrow cells from an HL-A matched and mixed leukocyte culture non-reactive sister. The graft was successfully established as shown by cytogenetic studies but was rejected after approximately 4 weeks. In preparation for a second transplant he was given procarbazine 12.5 mg/kg and goat antihuman thymocyte globulin (ATG) 7 mg/kg administered on alternate days for a total of 4 doses of each agent. At the end of this therapy his white blood cell count was noted to be going up and the second transplant was not carried out. Complete hematologic recovery of host type marrow ensued and persists now 20 months later. The various pathophysiologic mechanisms that may be involved are discussed.
一名23岁患有严重特发性再生障碍性贫血的男性，通过在4天内每天给予50mg/kg的环磷酰胺（CY）来为骨髓移植做准备。然后他接受了来自一名HL - A匹配且混合淋巴细胞培养无反应的姐姐的9.5×10⁹个骨髓细胞的静脉输注。细胞遗传学研究显示移植物成功植入，但大约4周后被排斥。为准备第二次移植，他接受了丙卡巴肼12.5mg/kg以及山羊抗人胸腺细胞球蛋白（ATG）7mg/kg，二者隔日给药，每种药物各共4剂。在该治疗结束时，发现他的白细胞计数在上升，于是未进行第二次移植。随后宿主型骨髓实现了完全血液学恢复，并且在20个月后的现在仍持续如此。文中讨论了可能涉及的各种病理生理机制。
