通过酶辅助合成制备两种人胰岛素突变体形式，其在B24或B25位含有亮氨酸。 - Suppr

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超能文献

The preparation of two mutant forms of human insulin, containing leucine in position B24 or B25, by enzyme-assisted synthesis.

作者信息

Gattner H G, Danho W, Behn C, Zahn H

出版信息

Hoppe Seylers Z Physiol Chem. 1980 Jul;361(7):1135-8.

PMID:6997173

Abstract

摘要

相似文献

The preparation of two mutant forms of human insulin, containing leucine in position B24 or B25, by enzyme-assisted synthesis.通过酶辅助合成制备两种人胰岛素突变体形式，其在B24或B25位含有亮氨酸。

Hoppe Seylers Z Physiol Chem. 1980 Jul;361(7):1135-8.

Diabetes-associated mutations in insulin: consecutive residues in the B chain contact distinct domains of the insulin receptor.胰岛素中与糖尿病相关的突变：B链中的连续残基与胰岛素受体的不同结构域相互作用。

Biochemistry. 2004 Jul 6;43(26):8356-72. doi: 10.1021/bi0497796.

Two mutant forms of human insulin. Structural consequences of the substitution of invariant B24- or B25-phenylalanine by leucine.人胰岛素的两种突变形式。B24位或B25位不变的苯丙氨酸被亮氨酸取代的结构后果。

Hoppe Seylers Z Physiol Chem. 1981 Jun;362(6):581-91. doi: 10.1515/bchm2.1981.362.1.581.

Diabetes-associated mutations in human insulin: crystal structure and photo-cross-linking studies of a-chain variant insulin Wakayama.人胰岛素中与糖尿病相关的突变：和歌山α链变体胰岛素的晶体结构与光交联研究

Biochemistry. 2005 Apr 5;44(13):5000-16. doi: 10.1021/bi047585k.

Diabetes mellitus caused by mutations in human insulin: analysis of impaired receptor binding of insulins Wakayama, Los Angeles and Chicago using pharmacoinformatics.由人类胰岛素突变引起的糖尿病：使用药物信息学分析和歌山、洛杉矶及芝加哥胰岛素的受体结合受损情况。

J Biomol Struct Dyn. 2017 Mar;35(4):724-737. doi: 10.1080/07391102.2016.1160258. Epub 2016 Apr 14.

Semisynthesis and biological properties of the [B24-leucine]-, [B25-leucine[- and [B24-leucine, B25-leucine]-analogues of human insulin.人胰岛素的[B24-亮氨酸]、[B25-亮氨酸]和[B24-亮氨酸，B25-亮氨酸]类似物的半合成及其生物学性质

Experientia. 1981;37(8):811-3. doi: 10.1007/BF01985653.

Shortened insulin analogues: marked changes in biological activity resulting from replacement of TyrB26 and N-methylation of peptide bonds in the C-terminus of the B-chain.短效胰岛素类似物：B链C末端的TyrB26被取代以及肽键N-甲基化导致生物活性发生显著变化。

Biochemistry. 2004 Mar 2;43(8):2323-31. doi: 10.1021/bi036001w.

Identification of a mutant human insulin predicted to contain a serine-for-phenylalanine substitution.鉴定出一种预测含有苯丙氨酸被丝氨酸取代的突变型人胰岛素。

Proc Natl Acad Sci U S A. 1983 Dec;80(24):7390-4. doi: 10.1073/pnas.80.24.7390.

Lilly lecture 1983. Abnormal products of the human insulin gene.1983年礼来讲座。人胰岛素基因的异常产物。

Diabetes. 1984 Jul;33(7):693-9. doi: 10.2337/diab.33.7.693.

Solution structure of the superactive monomeric des-[Phe(B25)] human insulin mutant: elucidation of the structural basis for the monomerization of des-[Phe(B25)] insulin and the dimerization of native insulin.超活性单体去-[苯丙氨酸（B25）]人胰岛素突变体的溶液结构：去-[苯丙氨酸（B25）]胰岛素单体化及天然胰岛素二聚化的结构基础解析

J Mol Biol. 1996 Apr 5;257(3):684-99. doi: 10.1006/jmbi.1996.0194.

引用本文的文献

Structural integrity of the B24 site in human insulin is important for hormone functionality.人胰岛素 B24 位点的结构完整性对于激素功能很重要。

J Biol Chem. 2013 Apr 12;288(15):10230-40. doi: 10.1074/jbc.M112.448050. Epub 2013 Feb 27.

Experientia. 1981;37(8):811-3. doi: 10.1007/BF01985653.

[LeuB24]insulin and [AlaB24]insulin: altered structures and cellular processing of B24-substituted insulin analogs.[亮氨酸B24]胰岛素和[丙氨酸B24]胰岛素：B24取代胰岛素类似物的结构改变与细胞加工过程

Proc Natl Acad Sci U S A. 1982 Sep;79(17):5147-51. doi: 10.1073/pnas.79.17.5147.

Trypsin-catalysed formation of pig des-(23-63)-proinsulin from desoctapeptide-(B23-30)-insulin.胰蛋白酶催化由去八肽-（B23-30）-胰岛素形成猪去-（23-63）-胰岛素原。

Biochem J. 1986 Mar 15;234(3):665-70. doi: 10.1042/bj2340665.

Negative and positive site-site interactions, and their modulation by pH, insulin analogs, and monoclonal antibodies, are preserved in the purified insulin receptor.负性和正性的位点间相互作用，以及它们受pH、胰岛素类似物和单克隆抗体的调节作用，在纯化的胰岛素受体中得以保留。

Proc Natl Acad Sci U S A. 1988 Nov;85(22):8400-4. doi: 10.1073/pnas.85.22.8400.

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