Zone J J, LaSalle B A, Provost T T
J Invest Dermatol. 1980 Aug;75(2):152-5. doi: 10.1111/1523-1747.ep12522539.
There is some evidence that dermatitis herpetiformis may be mediated by circulating immune complexes. This study attempts to define the antibody class of these complexes. All patients studied demonstrated granular deposition of IgA in the papillary dermis on direct immunofluorescence. Serum immune complexes were detected using the qualitative Raji cell immunofluorescent assay, as well as the quantitative immunoradiometric assay. A group of 25 dermatitis herpetiformis patients was found to have higher levels of IgA containing complexes compared to a group of normals (p < .01). Higher levels of IgG containing complexes were also noted in dermatitis herpetiformis patients at a low level of statistical significance (p < .1). The relationship of these complexes to the pathogenesis of dermatitis herpetiformis is yet to be determined.
有证据表明，疱疹样皮炎可能由循环免疫复合物介导。本研究旨在确定这些复合物的抗体类别。所有研究的患者在直接免疫荧光检查中均显示乳头真皮层有IgA颗粒沉积。使用定性Raji细胞免疫荧光测定法以及定量免疫放射测定法检测血清免疫复合物。发现一组25例疱疹样皮炎患者与一组正常人相比，含IgA复合物的水平更高（p <.01）。在疱疹样皮炎患者中也发现含IgG复合物的水平较高，但具有较低的统计学显著性（p <.1）。这些复合物与疱疹样皮炎发病机制的关系尚待确定。
