Clegg D O, Zone J J, Samuelson C O, Ward J R
Ann Rheum Dis. 1985 Apr;44(4):239-44. doi: 10.1136/ard.44.4.239.
Thirteen patients were studied after jejunoileal bypass (JIB) surgery. Seven developed arthritis and six did not. Circulating immune complexes containing IgG and IgA were detected in the sera of patients with and without arthritis. IgA complexes were shown to contain secretory component, a protein predominantly associated with intraluminal IgA, in significantly higher levels in patients with arthritis. Analytical ultracentrifugation showed complexes of approximately 10 X 8S, consistent with the size of secretory IgA. Arthritis after JIB appears to be associated with circulating immune complexes containing secretory IgA.
对13例接受空肠回肠旁路术（JIB）的患者进行了研究。7例出现关节炎，6例未出现。在患有关节炎和未患关节炎的患者血清中均检测到含有IgG和IgA的循环免疫复合物。结果显示，关节炎患者体内的IgA复合物含有分泌成分（一种主要与肠腔内IgA相关的蛋白质），其水平显著更高。分析超速离心显示复合物大小约为10×8S，与分泌型IgA的大小一致。空肠回肠旁路术后的关节炎似乎与含有分泌型IgA的循环免疫复合物有关。
