空肠回肠旁路术后疾病中含分泌型IgA的循环免疫复合物

Circulating immune complexes containing secretory IgA in jejunoileal bypass disease.

作者信息

Clegg D O, Zone J J, Samuelson C O, Ward J R

出版信息

Ann Rheum Dis. 1985 Apr;44(4):239-44. doi: 10.1136/ard.44.4.239.

DOI:10.1136/ard.44.4.239

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1001619/

Abstract

Thirteen patients were studied after jejunoileal bypass (JIB) surgery. Seven developed arthritis and six did not. Circulating immune complexes containing IgG and IgA were detected in the sera of patients with and without arthritis. IgA complexes were shown to contain secretory component, a protein predominantly associated with intraluminal IgA, in significantly higher levels in patients with arthritis. Analytical ultracentrifugation showed complexes of approximately 10 X 8S, consistent with the size of secretory IgA. Arthritis after JIB appears to be associated with circulating immune complexes containing secretory IgA.

摘要

对13例接受空肠回肠旁路术（JIB）的患者进行了研究。7例出现关节炎，6例未出现。在患有关节炎和未患关节炎的患者血清中均检测到含有IgG和IgA的循环免疫复合物。结果显示，关节炎患者体内的IgA复合物含有分泌成分（一种主要与肠腔内IgA相关的蛋白质），其水平显著更高。分析超速离心显示复合物大小约为10×8S，与分泌型IgA的大小一致。空肠回肠旁路术后的关节炎似乎与含有分泌型IgA的循环免疫复合物有关。

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本文引用的文献

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IgA-containing circulating immune complexes in dermatitis herpetiformis, Henoch-Schönlein purpura, systemic lupus erythematosus and other diseases.疱疹样皮炎、过敏性紫癜、系统性红斑狼疮及其他疾病中含IgA的循环免疫复合物

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The bowel bypass syndrome: a response to bacterial peptidoglycans.肠道旁路综合征：对细菌肽聚糖的一种反应。

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Articular complications of jejunoileal bypass surgery.空肠回肠分流术的关节并发症

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The intestinal bypass: arthritis-dermatitis syndrome.肠道旁路术：关节炎-皮炎综合征

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