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头孢孟多在小儿感染中的实验室及临床研究(作者译)

[Laboratory and clinical studies of cefamandole in pediatric infections (author's transl)].

作者信息

Kawamura M, Uozumi K, Maki T, Tauchi N, Takashima Y

出版信息

Jpn J Antibiot. 1980 Apr;33(4):429-32.

PMID:6997532
Abstract

Five patients with suppurative tonsillitis (1), urinary tract infection (1), staphylococcal impetigo (1), cervical lymphadenitis (1) and mycoplasma pneumonia were treated with cefamandole (CMD). CMD was administered by one shot intravenous or drip infusion at a dosage of 100 approximately 135 mg/kg/day for 4 approximately 14 days. Of 5 patients with those infections, excellent response was obtained in 3 patients, good response in 1 patient and unknown response in 1 patient. The overall efficacy rate was 100% except unknown response in mycoplasma pneumonia. In 3 of these 5 cases causative organisms were S. epidermidis, E. coli, and S. aureus, respectively. These organisms were all eliminated. No side effects were observed.

摘要

5例患有化脓性扁桃体炎(1例)、尿路感染(1例)、葡萄球菌性脓疱病(1例)、颈部淋巴结炎(1例)和支原体肺炎的患者接受了头孢孟多(CMD)治疗。CMD通过单次静脉注射或滴注给药,剂量为100至135mg/kg/天,持续4至14天。在这5例感染患者中,3例获得了优异反应,1例获得了良好反应,1例反应未知。除支原体肺炎反应未知外,总体有效率为100%。在这5例病例中的3例中,病原体分别为表皮葡萄球菌、大肠杆菌和金黄色葡萄球菌。这些病原体均被清除。未观察到副作用。

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