Gimeno M F, Borda E S, Lazzari M A, Gimeno A L
Prostaglandins. 1980 Aug;20(2):223-32. doi: 10.1016/s0090-6980(80)80041-4.
The influence of sex steroids on the production of prostacyclin (PGI2) like material by the isolated rat uterus incubated in a buffer medium was explored by monitoring its ability to inhibit ADP-induced platelet aggregation. Chopped uterine strips from rats in natural estrus can generate an unstable substance that inhibits platelet aggregation and suggest to be prostacyclin. This capacity was significantly enhanced in preparations from spayed animals. The injection of 17-beta estradiol; progesterone or both diminished the production of the prostacyclin-like material by the uterus from ovariectomized rats. The already existing notion that ovarian steroids are able to regulate the synthesis of stable prostaglandins is discussed together with the present results suggesting in addition a depressive effect of sex hormones on the uterine PGI2 synthetase system.
通过监测其抑制ADP诱导的血小板聚集的能力，探讨了性类固醇对在缓冲介质中孵育的离体大鼠子宫产生前列环素（PGI2）样物质的影响。来自处于自然发情期大鼠的切碎子宫条能够产生一种抑制血小板聚集的不稳定物质，提示其为前列环素。这种能力在去卵巢动物的制备物中显著增强。注射17-β雌二醇、孕酮或两者均会减少去卵巢大鼠子宫中前列环素样物质的产生。讨论了卵巢类固醇能够调节稳定前列腺素合成这一已有的观点，同时目前的结果还表明性激素对子宫PGI2合成酶系统有抑制作用。
