von Baehr R, Wuchatsch H, Perlberg K W
Arch Exp Veterinarmed. 1980;34(1):15-8.
Immunogenicity of live vaccine was not substantively affected by physiological antibody doses. Antibody did not change in vivo germ survival rates. The vaccine germ was isolated by tissue culturing from spleen and liver even after 42 days. Elimination from circulation was accelerated by antibody. The immunisation dose of pathogenic germs was considerably increased by means of specific immunoglobulins, which altogether improved the immunisation effect. Immunogenicity can be increased by antibody only in an indirect way and by means of vaccine doses generally not tolerated.
活疫苗的免疫原性并未受到生理抗体剂量的实质性影响。抗体未改变体内病菌存活率。即使在42天后,仍可通过组织培养从脾脏和肝脏中分离出疫苗病菌。抗体加速了病菌从循环系统中的清除。通过特异性免疫球蛋白可显著提高致病病菌的免疫剂量,总体上提高了免疫效果。抗体只能以间接方式且通过通常无法耐受的疫苗剂量来提高免疫原性。