Freund N, Kervran A, Assan R, Geloso J P, Girard J
Biol Neonate. 1980;38(5-6):321-7. doi: 10.1159/000241382.
Phloridzin, an inhibitor of renal sugar transport, produces an important loss of glucose in urine of treated animals. In order to reduce severely the maternal glucose supply to the fetuses in short-term experiments, we have combined phloridzin administration to pregnant rats with 18 h starvation. Fetuses from starved phloridzin-treated mothers were compared with fetuses from starved mothers. Combined treatment markedly decreases fetal blood glucose concentration (-36%) and fetal liver glycogen stores (-76%). These changes are associated with a decrease in plasma insulin (-25%), a rise in plasma glucagon (+120%) and a marked increase of hepatic PEPCK activity (+400%). It appears from these results that phloridzin treatment for a short duration is able to induce glycogenolysis and the premature appearance of PEPCK in the liver of rat fetuses.
根皮苷是一种肾糖转运抑制剂，可使接受治疗的动物尿液中出现大量葡萄糖流失。为了在短期实验中大幅减少母体向胎儿供应的葡萄糖，我们将给怀孕大鼠注射根皮苷与18小时禁食相结合。将饥饿状态下接受根皮苷治疗的母亲所生的胎儿与饥饿母亲所生的胎儿进行比较。联合治疗显著降低了胎儿血糖浓度（-36%）和胎儿肝脏糖原储备（-76%）。这些变化伴随着血浆胰岛素水平降低（-25%）、血浆胰高血糖素水平升高（+120%）以及肝脏磷酸烯醇式丙酮酸羧激酶（PEPCK）活性显著增加（+400%）。从这些结果看来，短期的根皮苷治疗能够诱导大鼠胎儿肝脏中的糖原分解以及PEPCK的过早出现。
