Ktorza A, Girard J R, Kinebanyan M F, Picon L
Diabetologia. 1981 Dec;21(6):569-74. doi: 10.1007/BF00281551.
Continuous glucose infusion was used to induced mild hyperglycaemia in unrestrained pregnant rats during the last three days of pregnancy. Control pregnant rats were infused with distilled water. Fetuses were studied after normal or prolonged pregnancy. Fetuses from glucose-infused rats, compared with controls, showed higher plasma glucose levels, increased plasma insulin and lower plasma glucagon concentrations. Pregnancy prolonged until day 23.5 resulted in a rise in the glucagon/insulin ratio from 6.5 to 67 in fetuses from control rats and from 1.3 to 13 in fetuses from glucose-infused rats. Concurrently in fetuses from control rats, liver phosphoenolpyruvate carboxykinase activity increased markedly and liver glycogen stores decreased sharply. In fetuses from glucose-infused rats, liver phosphoenolpyruvate carboxykinase activity rose and glycogen content decreased, but to a lesser extent. These results show that both the A and B cells of the rat fetal pancreas are sensitive to chronic glucose stimulation.
在妊娠的最后三天，对未受限的妊娠大鼠持续输注葡萄糖以诱导轻度高血糖。对照妊娠大鼠输注蒸馏水。在正常或延长妊娠后对胎儿进行研究。与对照组相比，输注葡萄糖的大鼠的胎儿表现出血浆葡萄糖水平升高、血浆胰岛素增加和血浆胰高血糖素浓度降低。妊娠延长至第23.5天导致对照大鼠胎儿的胰高血糖素/胰岛素比值从6.5升至67，输注葡萄糖的大鼠胎儿的该比值从1.3升至13。同时，对照大鼠胎儿的肝脏磷酸烯醇丙酮酸羧激酶活性显著增加，肝脏糖原储备急剧减少。在输注葡萄糖的大鼠胎儿中，肝脏磷酸烯醇丙酮酸羧激酶活性升高，糖原含量降低，但程度较小。这些结果表明，大鼠胎儿胰腺的A细胞和B细胞对慢性葡萄糖刺激均敏感。
