Ferrone R A, Heran C L, Antonaccio M J
Clin Exp Hypertens (1978). 1980 Feb;2(2):247-72. doi: 10.3109/10641968009046423.
The present study compared the hemodynamic effects of captopril with those of guanethidine as well as with a combination of these two drugs in conscious male spontaneously hypertensive rats. Acutely, captopril or guanethidine or a combination of the two lowered arterial pressure to similar levels. The reduction in pressure with captopril alone or in combination with guanethidine, was due to a lowering of all organ vascular resistances. Guanethidine alone lowered pressure by reducing cardiac output. Chronically, captopril or guanethidine lowered arterial pressure to similar levels by reducing organ vascular resistances to comparable levels, particularly skeletal muscle, skin and splanchnic organs. Combination of these two drugs had an additive effect on the reduction of arterial pressure and organ vascular resistances. Since, chronically, the addition of guanethidine to captopril therapy enhanced rather than attenuated the hemodynamic changes induced by captopril, these drugs are probably acting by different mechanisms and the mechanisms of action of captopril does not require an intact sympathetic nervous system.
本研究比较了卡托普利与胍乙啶以及这两种药物联合使用对清醒雄性自发性高血压大鼠的血流动力学影响。急性给药时，卡托普利、胍乙啶或二者联合用药均可使动脉血压降至相似水平。单独使用卡托普利或与胍乙啶联合使用时，血压降低是由于所有器官血管阻力下降所致。单独使用胍乙啶则通过降低心输出量来降低血压。长期给药时，卡托普利或胍乙啶通过将器官血管阻力降低至相当水平，特别是骨骼肌、皮肤和内脏器官的血管阻力，从而使动脉血压降至相似水平。这两种药物联合使用对降低动脉血压和器官血管阻力具有相加作用。由于长期来看，在卡托普利治疗中加用胍乙啶会增强而非减弱卡托普利引起的血流动力学变化，因此这些药物可能通过不同机制发挥作用，且卡托普利的作用机制并不需要完整的交感神经系统。
