Pochiero M, Nicoletta P, Losi E, Bianchi A, Caputi A P
Pharmacol Res Commun. 1983 Feb;15(2):173-82. doi: 10.1016/s0031-6989(83)80059-9.
The effect on blood pressure and heart rate, following administration of the same intracerebroventricular (ivt) and intravenous (iv) doses of captopril, was compared in freely moving DOCA-salt hypertensive rats, with chronically implanted ivt, iv and intraarterial cannulae. Ivt captopril (500 micrograms) in DOCA-salt rats showed an initial pressor response followed by a long lasting hypotensive effect. The ivt effect was greater than that following iv administration. No effect was observed in normotensive controls either ivt or iv. ASA or naloxone pretreatments significantly lowered the captopril hypotensive effect, thus suggesting an involvement of prostaglandin and opioid systems in blood pressure elevation in "non renin dependent" hypertension.
在自由活动的去氧皮质酮盐（DOCA-盐）高血压大鼠中，通过长期植入脑室内（ivt）、静脉内（iv）和动脉内插管，比较了给予相同脑室内和静脉内剂量的卡托普利后对血压和心率的影响。DOCA-盐大鼠脑室内注射卡托普利（500微克）显示出最初的升压反应，随后是持久的降压作用。脑室内注射的效果大于静脉注射。无论是脑室内注射还是静脉注射，在正常血压对照中均未观察到效果。阿司匹林或纳洛酮预处理显著降低了卡托普利的降压作用，因此表明前列腺素和阿片系统参与了“非肾素依赖性”高血压的血压升高过程。
