γ-谷维素对大鼠垂体激素分泌的影响（作者译）

[The effect of gamma-oryzanol on rat pituitary hormone secretion (author's transl)].

作者信息

Yamauchi J, Takahara J, Uneki T, Yakushiji W, Nakashima Y, Miyoshi M, Ofuji T

出版信息

Nihon Naibunpi Gakkai Zasshi. 1980 Aug 20;56(8):1130-9. doi: 10.1507/endocrine1927.56.8_1130.

DOI:10.1507/endocrine1927.56.8_1130

Abstract

gamma-oryzanol (gamma-OZ), a ferulic acid ester of triterpene alcohol, was investigated with regard to its effect on pituitary LH, GH, prolactin and TSH secretion in normal male (M) and ovariectomized female (OVX) rats. gamma-OZ showed a suppressive tendency of LH by a single intravenous injection and also markedly reduced the LH release induced by LHRH when compared with only vehicle-dosed control groups in M and OVX rats. Serum prolactin release induced by TRH was markedly suppressed by 6 days pretreatment with gamma-OZ in OVX rats. These data suggest that gamma-OZ is a potent inhibitor of LH release and may be a weak inhibitor of prolactin in rats.

摘要

γ-谷维素（γ-OZ），一种三萜醇的阿魏酸酯，研究了其对正常雄性（M）和去卵巢雌性（OVX）大鼠垂体促黄体生成素（LH）、生长激素（GH）、催乳素和促甲状腺激素（TSH）分泌的影响。单次静脉注射γ-OZ显示出对LH的抑制趋势，并且与仅给予赋形剂的M组和OVX组对照组相比，还显著降低了促性腺激素释放激素（LHRH）诱导的LH释放。在OVX大鼠中，γ-OZ预处理6天可显著抑制促甲状腺激素释放激素（TRH）诱导的血清催乳素释放。这些数据表明，γ-OZ是大鼠LH释放的有效抑制剂，可能是催乳素的弱抑制剂。