Ieiri T, Kase N, Hashigami Y, Kobori H, Nakamura T, Shimoda S
Nihon Naibunpi Gakkai Zasshi. 1982 Oct 20;58(10):1350-6. doi: 10.1507/endocrine1927.58.10_1350.
The effects of gamma oryzanol (gamma-OZ), a ferulic acid of triterpene alcohol, on the synthesis and release of the growth hormone (GH) and prolactin (PRL) in vitro and turnover rates of hypothalamic catecholamines were investigated. A single subcutaneous injection of 20 mg/kg of gamma-OZ suppressed GH synthesis and PRL release 1 hour after the injection. gamma-OZ increased medial basal hypothalamic (MBH) dopamine (DA) content, and the DA content was decreased by a treatment of alpha-methyl-p-tyrosine (alpha MpT), a tyrosine hydroxylase inhibitor, indicating increased synthesis and release of DA in MBH by gamma-OZ. gamma-OZ did not alter norepinephrine (NE) content in MBH, while the NE content was significantly decreased, indicating unchanged synthesis and increased release of NE in MBH by gamma-OZ. These results may explain the previous data concerning the changes in serum levels of GH and PRL by gamma-OZ and also suggest that gamma-OZ can affect the synthesis and/or release of at least two hypothalamic neurotransmitters, DA and NE, resulting in the alterations of anterior pituitary hormone synthesis and/or release.
研究了γ-谷维素（γ-OZ，一种三萜醇阿魏酸）对体外生长激素（GH）和催乳素（PRL）合成与释放以及下丘脑儿茶酚胺周转率的影响。单次皮下注射20mg/kg的γ-OZ可在注射后1小时抑制GH合成和PRL释放。γ-OZ增加了下丘脑内侧基底部（MBH）多巴胺（DA）含量，而酪氨酸羟化酶抑制剂α-甲基对酪氨酸（α-MpT）处理可降低DA含量，这表明γ-OZ增加了MBH中DA的合成与释放。γ-OZ未改变MBH中去甲肾上腺素（NE）含量，而NE含量显著降低，这表明γ-OZ使MBH中NE的合成不变但释放增加。这些结果可能解释了先前关于γ-OZ导致血清GH和PRL水平变化的数据，并且还表明γ-OZ可影响至少两种下丘脑神经递质DA和NE的合成和/或释放，从而导致垂体前叶激素合成和/或释放的改变。
