Goldstein I, Renais J, Scebat L
Isr J Med Sci. 1980 Aug;16(8):566-71.
Thirty-seven rabbits were immunized against lipopolysaccharide from Escherichia coli or Salmonella enteritidis over a period of up to 16 months. The animals developed antibodies against rabbit renal glycoproteins and against bacterial polysaccharide; they also showed signs of kidney lesions. The immunoperoxidase test showed antibody and complement (C3) fixation on the periphery of glomeruli and tubules. Antibodies extracted from the kidneys of the immunized animals reacted with isologous and autologous renal glycoproteins, suggesting that the renal lesions were due to an immunologic response. The cross-reactivity between the bacterial lipopolysaccharide and the renal glycoproteins appears to be responsible for these lesions.
37只兔子在长达16个月的时间里接受了针对大肠杆菌或肠炎沙门氏菌脂多糖的免疫。这些动物产生了针对兔肾糖蛋白和细菌多糖的抗体；它们还表现出肾脏病变的迹象。免疫过氧化物酶试验显示抗体和补体（C3）固定在肾小球和肾小管周围。从免疫动物的肾脏中提取的抗体与同种和自体肾糖蛋白发生反应，表明肾脏病变是由免疫反应引起的。细菌脂多糖和肾糖蛋白之间的交叉反应似乎是这些病变的原因。
